Optimization of Hypertension Treatment using Fixed-Dose Combination of Perindropril/Amlodipine
Abstract
A lot of hypertensive patients require two or more antihypertensive drugs to control and maintain normal blood pressure. Combination of antihypertension is recommended either as first or second line treatment. Among available antihypertension medications, combination of renin-angiotensinaldosteron (RAAS) inhibitor with calcium channel blocker or diuretics are more recommended as they have sinergistic clinical and biomolecular effects.Furthermore, single pill dosage is associated with higher patients compliants and lower faults incidence in medication. Severeal fixed-dose combinations are currently available in the market to give easier hypertension control and patients compliants. This short review focus on combination of perindropril and amlodipine
Downloads
Download data is not yet available.
References
1. World Health Organization. Global health risks: mortality and burden of disease attributable to selected major risks. Geneva: WHO Press; 2009
2. Mancia G, De Backer G, Dominiczak A, et al. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007 Jun; 25(6): 1105–87
3. Mancia G, Laurent S, Agabiti-Rosei E, et al. Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. J Hypertension 2009 Nov; 27(11): 2121–58
4. Ferrari R. Optimizing the treatment of hypertension and stable coronary artery disease: clinical evidence for fixed-combination perindopril/amlodipine. Curr Med Res Opin 2008 Dec; 24(12): 3543–57
5. Messerli FH. Vasodilatory edema: a common side effect of antihypertensive therapy. Curr Cardiol Rep 2002 Nov; 4(6): 479–82
6. Messerli FH, Weir MR, Neutel JM. Combination therapy of amlodipine/benazepril versus monotherapy of amlodipine in a practice-based setting. Am J Hypertension 2002 Jun; 15(6): 550–6
7. Dahlöf B, Sever PS, Poulter NR, et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicenter randomized controlled trial. Lancet 2005 Sep 10–16; 366(9489): 895–906
8. Wang X, Gong L, Guo J, et al. Parallel comparative trial of amlodipine and nitrendipine monotherapy in patients with essential hypertension. J Hypertens Suppl. 1998 Sep; 16(4): S43–7
9. Navarro Estrada JL, Oliveri R. Long-term efficacy of amlodipine in patients with severe coronary artery disease. J Cardiovasc Pharmacol 1993; 22 Suppl. A: S24–8
10. Deanfield JE, Detry JM, Lichtlen PR, et al. Amlodipine reduces transient myocardial ischemia in patients with coronary artery disease: double-blind Circadian Anti-Ischemia Program in Europe (CAPE Trial). J Am Coll Cardiol 1994 Nov 15; 24(6): 1460–7
11. Wang JG, Li Y, Franklin SS, et al. Prevention of stroke and myocardial infarction by amlodipine and angiotensin receptor blockers: a quantitative overview. Hypertension 2007 Jul; 50(1): 181–8
12. Fox KM. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003 Sep 6; 362(9386): 782–8
13. PROGRESS Collaborative group. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet 2001 Sep 29; 358(9287): 1033–41
14. Ferrari R. Effects of angiotensin-converting enzyme inhibition with perindopril on left ventricular remodeling and clinical outcome: results of the randomized Perindopril and Remodeling in Elderly with Acute Myocardial Infarction (PREAMI) Study. Arch Intern Med 2006 Mar 27; 166(6): 659–66
15. Ogilvie RI, Anand S, Roy P, et al. Perindopril for control of blood pressure in patients with hypertension and other cardiovascular risk factors: an open-label, observational, multicenter, general practice-based study. Clinical Drug Investigation 2008; 28(11): 673–86
16. Ceconi C, Fox KM, Remme WJ, et al. ACE inhibition with perindopril and endothelial function. Results of a substudy of the EUROPA study: PERTINENT. Cardiovascular Res 2007 Jan 1; 73(1): 237–46
17. Bahl VK, Jadhav UM, Thacker HP. Management of hypertension with the fixed combination of perindopril and amlodipine in daily clinical practice: results from the STRONG prospective, observational, multicenter study. Am J Cardiovascular Drugs 2009; 9(3): 135–42
18. Weber MA, Julius S, Kjeldsen SE, et al. Blood pressure dependent and independent effects of antihypertensive treatment on clinical events in the VALUE Trial. Lancet 2004 Jun 19; 363(9426): 2049–51
19. Physicians’ Desk Reference. Montvale (NJ): Medical Economics Company; 2008
2. Mancia G, De Backer G, Dominiczak A, et al. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007 Jun; 25(6): 1105–87
3. Mancia G, Laurent S, Agabiti-Rosei E, et al. Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. J Hypertension 2009 Nov; 27(11): 2121–58
4. Ferrari R. Optimizing the treatment of hypertension and stable coronary artery disease: clinical evidence for fixed-combination perindopril/amlodipine. Curr Med Res Opin 2008 Dec; 24(12): 3543–57
5. Messerli FH. Vasodilatory edema: a common side effect of antihypertensive therapy. Curr Cardiol Rep 2002 Nov; 4(6): 479–82
6. Messerli FH, Weir MR, Neutel JM. Combination therapy of amlodipine/benazepril versus monotherapy of amlodipine in a practice-based setting. Am J Hypertension 2002 Jun; 15(6): 550–6
7. Dahlöf B, Sever PS, Poulter NR, et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicenter randomized controlled trial. Lancet 2005 Sep 10–16; 366(9489): 895–906
8. Wang X, Gong L, Guo J, et al. Parallel comparative trial of amlodipine and nitrendipine monotherapy in patients with essential hypertension. J Hypertens Suppl. 1998 Sep; 16(4): S43–7
9. Navarro Estrada JL, Oliveri R. Long-term efficacy of amlodipine in patients with severe coronary artery disease. J Cardiovasc Pharmacol 1993; 22 Suppl. A: S24–8
10. Deanfield JE, Detry JM, Lichtlen PR, et al. Amlodipine reduces transient myocardial ischemia in patients with coronary artery disease: double-blind Circadian Anti-Ischemia Program in Europe (CAPE Trial). J Am Coll Cardiol 1994 Nov 15; 24(6): 1460–7
11. Wang JG, Li Y, Franklin SS, et al. Prevention of stroke and myocardial infarction by amlodipine and angiotensin receptor blockers: a quantitative overview. Hypertension 2007 Jul; 50(1): 181–8
12. Fox KM. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003 Sep 6; 362(9386): 782–8
13. PROGRESS Collaborative group. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet 2001 Sep 29; 358(9287): 1033–41
14. Ferrari R. Effects of angiotensin-converting enzyme inhibition with perindopril on left ventricular remodeling and clinical outcome: results of the randomized Perindopril and Remodeling in Elderly with Acute Myocardial Infarction (PREAMI) Study. Arch Intern Med 2006 Mar 27; 166(6): 659–66
15. Ogilvie RI, Anand S, Roy P, et al. Perindopril for control of blood pressure in patients with hypertension and other cardiovascular risk factors: an open-label, observational, multicenter, general practice-based study. Clinical Drug Investigation 2008; 28(11): 673–86
16. Ceconi C, Fox KM, Remme WJ, et al. ACE inhibition with perindopril and endothelial function. Results of a substudy of the EUROPA study: PERTINENT. Cardiovascular Res 2007 Jan 1; 73(1): 237–46
17. Bahl VK, Jadhav UM, Thacker HP. Management of hypertension with the fixed combination of perindopril and amlodipine in daily clinical practice: results from the STRONG prospective, observational, multicenter study. Am J Cardiovascular Drugs 2009; 9(3): 135–42
18. Weber MA, Julius S, Kjeldsen SE, et al. Blood pressure dependent and independent effects of antihypertensive treatment on clinical events in the VALUE Trial. Lancet 2004 Jun 19; 363(9426): 2049–51
19. Physicians’ Desk Reference. Montvale (NJ): Medical Economics Company; 2008
Published
2015-12-04
Views & Downloads
Abstract views: 3890
PDF downloads: 3377
PDF downloads: 3377
How to Cite
Hindoro, E., & Karlina, A. (2015). Optimization of Hypertension Treatment using Fixed-Dose Combination of Perindropril/Amlodipine. Indonesian Journal of Cardiology, 36(1), 46-51. https://doi.org/10.30701/ijc.v36i1.442
Section
Review Article
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
